The plane was taking off from the north runway, when it crashed to the ground two miles from the airport, Sheikh Khalid Al Qasimi, director of civil aviation, told Arabian Business.
None of the six crew have been found. The accident happened at around 3.30pm.
In 2004, an Iranian plane crashed near Sharjah airport killing at least 43 people.
The Kish Airlines flight was coming in to land when reports it took a nosedive after asking for an emergency landing.