The sale means that one-way flights from Dubai can be purchased for as low as AED100 to Doha and AED125 only to Beirut, Amman and Bahrain.
The carrier added that 50 percent discounts were also available on flights to Djibouti, Khartoum, Baku, Aleppo, Damascus and Kathmandu.
Bookings must be made before 11.59pm on December 15 for travel between January 7 and March 27, 2010.
Ghaith Al Ghaith, CEO of flydubai said: "The flydubai sale is an important part of our business strategy and will continue to be a regular feature. Our previous two sales have generated a huge amount of excitement and interest and we expect the same from this one."