World number one Donald shot a closing 66 to finish third in the tournament on 16-under 272, one behind fellow countryman Paul Lawrie (67) and three adrift of Quiros (67).
Donald, who had already clinched the US PGA Tour money list in October, picked up $1.5m for landing the European order of merit and another $487,500 for his performance at the Greg Norman-designed Earth course.
"I didn't think it was possible to win the money lists on both tours. This was never going to be an easy week but it has capped off an amazing year for me," he said.
The 28-year-old Quiros collected the first prize of $1.25m after making it a Dubai double - he also lifted the Desert Classic crown in February - by coaxing home a curling 50-feet eagle putt at the 18th.
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