Buildings were evacuated as emergency services were called to the scene, meanwhile social media users chimed in with their experience of the disaster.
"The fire on #SZR is massive, I can smell the smoke all the way in Nad Al Sheba," @xo_B_ posted on the micro-blogging website.
Firefighter were trying to save a major oil tank, reports Gulf News.
"Massive #Fire in #Dubai. Fire engines seen rushing towards safa park area. Smoke seen until Mall of Emirates #SZR," @blogliterati shared.
So far there is no word on how the fire started and no casualties have been reported.
"We received a call at 12.50pm reporting of a fire on Sheikh Zayed Road between Interchanges 2 and 3, with emergency teams arriving on the scene within minutes. The fire was brought under control by Civil Defence teams by 1.56pm,” a spokesman said.
"No one was seriously injured in the fire; however, the cause of the blaze is still under investigation."